Joint Transceiver Design for Dual-Functional Full-Duplex Relay Aided Radar-Communication Systems

Driven by the demand for massive and accurate sensing data to achieve wireless network intelligence under a limited available spectrum, the coexistence between radar and communication systems has attracted public attention. In this paper, we investigate a novel dual-functional full-duplex relay aided radar-communication system where the phased-array radar is employed at the amplify-and-forward (AF) relay. A joint transceiver design is proposed to maximize the minimum signal-to-interference-plus-noise ratio (SINR) among all detection directions at the radar receiver under communication quality-of-service and total energy constraints. The formulated optimization problem is particularly challenging due to the highly nonconvex objective function and constraints. Based on the problem structure, we equivalently decompose it into the radar-energy and relay-energy minimization problems under SINR requirements. To solve the radar-energy minimization problem, we propose a low-complexity algorithm based on the alternating direction method of multipliers to optimize the radar transmit power and receiver. The relay-energy minimization problem can be simplified into an equivalent quadratic programming problem by introducing an insightful unitary matrix. Then, the closed-form expression for the AF relay beamforming matrix can be derived, which is jointly determined by the channel condition of relay communication and the detection direction of the radar. After that, we introduce the overall transceiver design algorithm to the original problem and discuss its optimality and computational complexity. Simulation results verify that the proposed algorithm significantly outperforms other benchmark algorithms

Subspace methods for self-calibration of ULAs with unknown mutual coupling: A false-peak analysis

Self-calibration can mitigate the adverse effect of array imperfections in direction-of-arrival (DoA) estimation. In this paper, we consider self-calibration of uniform linear arrays (ULAs) with unknown mutual coupling and focus on subspace-based methods. By modeling the effect of mutual coupling through complex symmetric Toeplitz matrices, we first analyze its influence to existing subspace methods. Our analytical results illustrate that mutual coupling can induce false peaks in spatial spectra of these methods, and more importantly, most of these peaks are predictable. Based on the analytical results, we then propose new spectra to suppress these predictable false peaks, and new self-calibration algorithms for the proposed spectra. Simulations are performed to validate our analytical results and to illustrate the advantages of the proposed algorithms

The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

postprin

Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy

Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons. Studies using mouse models of SMA have revealed widespread heterogeneity in the susceptibility of individual motor neurons to neurodegeneration, but the underlying reasons remain unclear. Data from related motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), suggest that morphological properties of motor neurons may regulate susceptibility: in ALS larger motor units innervating fast-twitch muscles degenerate first. We therefore set out to determine whether intrinsic morphological characteristics of motor neurons influenced their relative vulnerability to SMA. Motor neuron vulnerability was mapped across 10 muscle groups in SMA mice. Neither the position of the muscle in the body, nor the fibre type of the muscle innervated, influenced susceptibility. Morphological properties of vulnerable and disease-resistant motor neurons were then determined from single motor units reconstructed in Thy.1-YFP-H mice. None of the parameters we investigated in healthy young adult mice - including motor unit size, motor unit arbor length, branching patterns, motor endplate size, developmental pruning and numbers of terminal Schwann cells at neuromuscular junctions - correlated with vulnerability. We conclude that morphological characteristics of motor neurons are not a major determinant of disease-susceptibility in SMA, in stark contrast to related forms of motor neuron disease such as ALS. This suggests that subtle molecular differences between motor neurons, or extrinsic factors arising from other cell types, are more likely to determine relative susceptibility in SMA

Graph editing to a given degree sequence

We investigate the parameterized complexity of the graph editing problem called Editing to a Graph with a Given Degree Sequence where the aim is to obtain a graph with a given degree sequence σ by at most k vertex deletions, edge deletions and edge additions. We show that the problem is W[1]-hard when parameterized by k for any combination of the allowed editing operations. From the positive side, we show that the problem can be solved in time 2O(k(Δ⁎+k)2)n2log⁡n for n -vertex graphs, where Δ⁎=max⁡σ, i.e., the problem is FPT when parameterized by k+Δ⁎. We also show that Editing to a Graph with a Given Degree Sequence has a polynomial kernel when parameterized by k+Δ⁎ if only edge additions are allowed, and there is no polynomial kernel unless NP⊆co-NP/poly for all other combinations of the allowed editing operations

Neanderthals on the Lower Danube: Middle Palaeolithic evidence in the Danube Gorges of the Balkans

The article presents evidence about the Middle Palaeolithic and Middle to Upper Palaeolithic transition interval in the karst area of the Danube Gorges in the Lower Danube Basin. We review the extant data and present new evidence from two recently investigated sites found on the Serbian side of the Danube River – Tabula Traiana and Dubočka-Kozja caves. The two sites have yielded layers dating to both the Middle and Upper Palaeolithic and have been investigated by the application of modern standards of excavation and recovery along with a suite of state-of-the-art analytical procedures. The presentation focuses on micromorphological analyses of the caves’ sediments, characterisation of cryptotephra, a suite of new radiometric dates (accelerator mass spectrometry and optically stimulated luminescence) as well as proteomics (zooarchaeology by mass spectrometry) and stable isotope data in discerning patterns of human occupation of these locales over the long term

Neanderthals on the Lower Danube: Middle Palaeolithic evidence in the Danube Gorges of the Balkans

The article presents evidence about the Middle Palaeolithic and Middle to Upper Palaeolithic transition interval in the karst area of the Danube Gorges in the Lower Danube Basin. We review the extant data and present new evidence from two recently investigated sites found on the Serbian side of the Danube River – Tabula Traiana and Dubočka-Kozja caves. The two sites have yielded layers dating to both the Middle and Upper Palaeolithic and have been investigated by the application of modern standards of excavation and recovery along with a suite of state-of-the-art analytical procedures. The presentation focuses on micromorphological analyses of the caves’ sediments, characterisation of cryptotephra, a suite of new radiometric dates (accelerator mass spectrometry and optically stimulated luminescence) as well as proteomics (zooarchaeology by mass spectrometry) and stable isotope data in discerning patterns of human occupation of these locales over the long term

In situ evidence for the structure of the magnetic null in a 3D reconnection event in the Earth's magnetotail

Magnetic reconnection is one of the most important processes in astrophysical, space and laboratory plasmas. Identifying the structure around the point at which the magnetic field lines break and subsequently reform, known as the magnetic null point, is crucial to improving our understanding reconnection. But owing to the inherently three-dimensional nature of this process, magnetic nulls are only detectable through measurements obtained simultaneously from at least four points in space. Using data collected by the four spacecraft of the Cluster constellation as they traversed a diffusion region in the Earth's magnetotail on 15 September, 2001, we report here the first in situ evidence for the structure of an isolated magnetic null. The results indicate that it has a positive-spiral structure whose spatial extent is of the same order as the local ion inertial length scale, suggesting that the Hall effect could play an important role in 3D reconnection dynamics.Comment: 14 pages, 4 figure

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage.

Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria. Colibactin-producing gut microbes promote colon tumour formation and enhance the progression of colorectal cancer via cellular senescence and death induced by DNA double-strand breaks (DSBs); however, the chemical basis that contributes to the pathogenesis at the molecular level has not been fully characterized. Here, we report the discovery of colibactin-645, a macrocyclic colibactin metabolite that recapitulates the previously assumed genotoxicity and cytotoxicity. Colibactin-645 shows strong DNA DSB activity in vitro and in human cell cultures via a unique copper-mediated oxidative mechanism. We also delineate a complete biosynthetic model for colibactin-645, which highlights a unique fate of the aminomalonate-building monomer in forming the C-terminal 5-hydroxy-4-oxazolecarboxylic acid moiety through the activities of both the polyketide synthase ClbO and the amidase ClbL. This work thus provides a molecular basis for colibactin's DNA DSB activity and facilitates further mechanistic study of colibactin-related colorectal cancer incidence and prevention

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity

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